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Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill. What do the latest studies tell us about this risk? And how should we interpret and communicate the results? It isn't easy for researchers to calculate the risk of transmission from an exposure to HIV through sex.
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Effective HIV prevention programs rely on accurate estimates of the per-act risk of HIV acquisition from sexual and parenteral exposures. We updated the previous risk estimates of HIV acquisition from parenteral, vertical, and sexual exposures, and assessed the modifying effects of factors including condom use, male circumcision, and antiretroviral therapy. We conducted literature searches to identify new studies reporting data regarding per-act HIV transmission risk and modifying factors. Of the abstracts potentially related to per-act HIV transmission risk, three meta-analyses provided pooled per-act transmission risk probabilities and two studies provided data on modifying factors. Of the abstracts related to modifying factors, 15 relevant articles, including three meta-analyses, were included. Risk of HIV transmission was greatest for blood transfusion, followed by vertical exposure, sexual exposures, and other parenteral exposures. Sexual exposure risks ranged from low for oral sex to infections per 10 exposures for receptive anal intercourse. Estimated risks of HIV acquisition from sexual exposure were attenuated by